Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, United Kingdom. Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, University Hospitals Birmingham, NHS Foundation Trust, Edgbaston, Birmingham, United Kingdom. Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham, United Kingdom, m.oreilly@bham.ac.uk. Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, University Hospitals Birmingham, NHS Foundation Trust, Edgbaston, Birmingham, United Kingdom, m.oreilly@bham.ac.uk.